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Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
untreated. Considering no FDA-approved vaccine exists, the creation of a safe and effective vaccine remains an important public health goal. A formalin-inactivated C. burnetii Nine Mile strain phase I whole-cell vaccine generates protective immunity in a...
Regeneration of insulin-producing [beta]-cells during recovery from disease: a cure for Type 1 Diabetes
(University of Missouri--Columbia, 2018)
to T1D upon transfer to 13R+/+ mice. These findings reveal new insights as to the role environmental IL-4/IL-13 and the HR play in peripheral tolerance and the development of T1D. In chapter III, we investigate the source of newly formed β-cells during...
Investigating the deleterious role of B lymphocytes during brucella infection
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a disease known for inducing chronic, often life-long, infections. While it is clear the host immune response fails to clear ...
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)
by or directly adjacent to lysosomal particles. In 2020, SARS-CoV-2 became a global pandemic, and many research efforts transitioned to finding treatments, vaccines, cures, and methods of understanding and tracking viral spread. It was soon noted that SARS-CoV-2...
Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)
Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ...